Sex-specific genetic architecture of human disease

I-40: The Genetic Complexities of Human Sex-Determination

Background - MaterialsAndMethods N;Results N;Conclusion N;

Sex-specific genetic architecture of whole blood serotonin levels.

Recently, a quantitative-trait locus (QTL) for whole blood serotonin level was identified in a genomewide linkage and association study in a founder population. Because serotonin level is a sexually dimorphic trait, in the present study, we evaluated the sex-specific genetic architecture of whole blood serotonin level in the same population. Here, we use an extended homozygosity-by-descent link...

Sex - Biased Gene Expression Resolves Sexual Conflict through the 1 Evolution of Sex - Specific Genetic Architecture

SEX - BIASED GENE EXPRESSION RESOLVES SEXUAL CONFLICT THROUGH THE 1 EVOLUTION OF SEX - SPECIFIC GENETIC ARCHITECTURE 2 3 Alison

Fundamental sex difference in human brain architecture.

In PNAS, a report by Ingalhalikar et al. (1) has the makings of a landmark paper. Here I would like to briefly suggest why. Biomedical research in general, and neuroscience in particular, has been built on a false assumption. I refer to the assumption that one may safely ignore potential sex influences, for essentially every domain outside sexual functions and sex-specific issues like prostate ...